Abstract
Increased oxygen consumption during aerobic exercise is one of the main cause of accompanied oxidative stress. Oxidative stress is a condition of a disturbed balance between reactive oxygen species (ROS), reactive nitrogen species (RNS) and antioxidative defense. Antioxidants are substances that reduce the damage caused by oxidative stress. Uric acid is one of the most important antioxidant. The aim of this study was to estimate the influence of acute exercise on uric acid serum levels in rats. Adults Wistar rats weighting between 280-330 g were divided into two groups: control group (n = 8) and exercise group (n = 8). Exercise group was exposed to acute bout of exercise (swimming), after short accommodation period. Control group was consisted of animals housed in the same condition without exercise sessions. Animals were sacrificed and blood sample was taken from the abdominal aorta to determine uric acid levels. Levels of uric acid in serum samples were determined by spectrophotometric method. Acute exercise (swimming) significantly increased average concentration of uric acid in exercise group (246.5 ± 19.1 mmol / l) when compared to control group (226.11 ± 7.8 mmol / l) (p = 0.03). Acute exercise increases the concentration of uric acid in serum probably as an antioxidant response to enhanced oxidative stress
