The aim of this research was to determine the effectiveness of different school-based physical activity (PA) interventions on body fat and BMI in female students. This research consisted of (n=106) healthy participants, who regularly attended school physical education (PE) classes. The research sample was divided in two observed groups, using different PA content. In the group A (n=53), PA content consisted of learning volleyball basics, while in the group B (n=53) it consisted of mastering volleyball, basketball games and different techniques, as well as athletics and sport gymnastics, based on regular school curriculum. The results have shown that there was no significant mean difference, based on p<0.05, neither in body fat (skinfolds) nor in BMI, after PA interventions in both groups. The conclusion of this research was that the choice of kinesiology operators, methodical work forms and application of PE content in time frame of one school year, were insufficient factors to achive success in reducing the level of BMI and adiposity. However, those factors played significant part in the prevention of overweight in general, together with other important factors such as total physical activity,health status and eating habits.